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We designed 2,6-bis(hydroxymethyl)anilines bearing protecting groups sensitive to UV light, acid, or base, and used the protected anilines as co-monomers for the synthesis of trigger-responsive polymers. The resulting polymers underwent chain-shattering degradation once the protecting groups were removed, which could be used for trigger-responsive burst release applications.

Graphical abstract: Trigger-responsive chain-shattering polymers

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