Jump to main content
Jump to site search

Issue 5, 2013
Previous Article Next Article

In situ generation of bioreducible and acid labile nanogels/microgels simply via adding water into the polymerization system

Author affiliations

Abstract

A novel and versatile method for one-pot and in situ generation of bioreducible and acid labile nanogels/microgels simply via adding water into the polymerization system is reported. The produced polymers in the polymerization system become temperature-sensitive and less soluble after adding water, and hence they collapse together, forming nanoparticles. Subsequently, the disulfides inside the nanoparticle undergo intermolecular disulfide exchange to crosslink the nanoparticle into a bioreducible and acid labile nanogel/microgel. The size of the nanogel/microgel can be easily controlled by the polymerization time and the amount of water added. The formed nanogel/microgel is redox and pH responsive, and biocompatible.

Graphical abstract: In situ generation of bioreducible and acid labile nanogels/microgels simply via adding water into the polymerization system

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Dec 2012, accepted on 18 Dec 2012 and first published on 19 Dec 2012


Article type: Paper
DOI: 10.1039/C2PY21058D
Polym. Chem., 2013,4, 1694-1699

  •   Request permissions

    In situ generation of bioreducible and acid labile nanogels/microgels simply via adding water into the polymerization system

    Z. Wang, L. Wang, J. Sun, L. Han and C. Hong, Polym. Chem., 2013, 4, 1694
    DOI: 10.1039/C2PY21058D

Search articles by author

Spotlight

Advertisements