Issue 38, 2013
From the journal:

Organic & Biomolecular Chemistry

Enantioselective synthesis of 3-hydroxy oxindoles by ytterbium-catalysed decarboxylative addition of β-ketoacids to isatins†

Zhiqiang Duan,a   Jianlin Han,ab   Ping Qian,a   Zirui Zhang,a   Yi Wang*ac  and  Yi Panac  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China
E-mail: yiwang@nju.edu.cn
Fax: +86-25-83309123
Tel: +86-25-83593153

b Institute for Chemistry & Biomedical Sciences, Nanjing University, Nanjing, China

c State of Key Laboratory of Coordination, Nanjing University, Nanjing, China

Abstract

A ytterbium(III)-indapybox catalysed enantioselective decarboxylative addition reaction of β-ketoacids to isatins is described. The biologically important 3-hydroxy oxindoles were obtained in high yields and excellent enantioselectivities.

Graphical abstract: Enantioselective synthesis of 3-hydroxy oxindoles by ytterbium-catalysed decarboxylative addition of β-ketoacids to isatins

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Article information

DOI
https://doi.org/10.1039/C3OB41460D
Article type
Communication
Submitted
16 Jul 2013
Accepted
02 Aug 2013
First published
05 Aug 2013

Org. Biomol. Chem., 2013,11, 6456-6459

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Enantioselective synthesis of 3-hydroxy oxindoles by ytterbium-catalysed decarboxylative addition of β-ketoacids to isatins

Z. Duan, J. Han, P. Qian, Z. Zhang, Y. Wang and Y. Pan, Org. Biomol. Chem., 2013, 11, 6456 DOI: 10.1039/C3OB41460D

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