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Issue 41, 2013
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Template-constrained cyclic sulfopeptide HIV-1 entry inhibitors

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Abstract

Template-constrained cyclic sulfopeptides that inhibit HIV-1 entry were rationally designed based on a loop from monoclonal antibody (mAb) 412d. A focused set of sulfopeptides was synthesized using Fmoc-Tyr(SO3DCV)-OH (DCV = 2,2-dichlorovinyl). Three cyclic sulfopeptides that inhibit entry of HIV-1 and complement the activity of known CCR5 antagonists were identified.

Graphical abstract: Template-constrained cyclic sulfopeptide HIV-1 entry inhibitors

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Article information


Submitted
08 Jul 2013
Accepted
14 Sep 2013
First published
17 Sep 2013

Org. Biomol. Chem., 2013,11, 7096-7100
Article type
Communication

Template-constrained cyclic sulfopeptide HIV-1 entry inhibitors

J. G. Rudick, M. M. Laakso, A. C. Schloss and W. F. DeGrado, Org. Biomol. Chem., 2013, 11, 7096
DOI: 10.1039/C3OB41395K

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