Jump to main content
Jump to site search

Issue 36, 2013
Previous Article Next Article

Synthesis of homogeneous MUC1 oligomers via a bi-directional ligation strategy

Author affiliations

Abstract

The efficient synthesis of homogeneous MUC1 peptide oligomers using sequential ligation reactions in the N-to-C and C-to-N directions is reported. The bi-directional ligation strategy makes use of thioester formation via N → S acyl shift chemistry in combination with peptide ligation reactions and was used to prepare a library of peptide oligomers ranging in molecular mass from 3.8–9.4 kDa, comprised of between 2 and 5 repeats of the MUC1 variable number tandem repeat sequence.

Graphical abstract: Synthesis of homogeneous MUC1 oligomers via a bi-directional ligation strategy

Back to tab navigation

Supplementary files

Publication details

The article was received on 14 May 2013, accepted on 30 Jul 2013 and first published on 31 Jul 2013


Article type: Paper
DOI: 10.1039/C3OB41363B
Org. Biomol. Chem., 2013,11, 6090-6096

  •   Request permissions

    Synthesis of homogeneous MUC1 oligomers via a bi-directional ligation strategy

    D. Al Sheikha, B. L. Wilkinson, G. Santhakumar, M. Thaysen-Andersen and R. J. Payne, Org. Biomol. Chem., 2013, 11, 6090
    DOI: 10.1039/C3OB41363B

Search articles by author

Spotlight

Advertisements