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Issue 36, 2013
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Synthesis of homogeneous MUC1 oligomers via a bi-directional ligation strategy

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Abstract

The efficient synthesis of homogeneous MUC1 peptide oligomers using sequential ligation reactions in the N-to-C and C-to-N directions is reported. The bi-directional ligation strategy makes use of thioester formation via N → S acyl shift chemistry in combination with peptide ligation reactions and was used to prepare a library of peptide oligomers ranging in molecular mass from 3.8–9.4 kDa, comprised of between 2 and 5 repeats of the MUC1 variable number tandem repeat sequence.

Graphical abstract: Synthesis of homogeneous MUC1 oligomers via a bi-directional ligation strategy

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Supplementary files

Article information


Submitted
14 May 2013
Accepted
30 Jul 2013
First published
31 Jul 2013

Org. Biomol. Chem., 2013,11, 6090-6096
Article type
Paper

Synthesis of homogeneous MUC1 oligomers via a bi-directional ligation strategy

D. Al Sheikha, B. L. Wilkinson, G. Santhakumar, M. Thaysen-Andersen and R. J. Payne, Org. Biomol. Chem., 2013, 11, 6090
DOI: 10.1039/C3OB41363B

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