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Issue 41, 2013
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Recent developments in Cope-type hydroamination reactions of hydroxylamine and hydrazine derivatives

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Abstract

Cope-type hydroaminations are versatile for the direct amination of alkenes, alkynes and allenes using hydroxylamines and hydrazine derivatives. These reactions occur via a concerted, 5-membered cyclic transition state that is the microscopic reverse of the Cope elimination. This article focuses on recent developments, including intermolecular variants, directed reactions, and asymmetric variants using aldehydes as tethering catalysts, and their applications in target-oriented synthesis.

Graphical abstract: Recent developments in Cope-type hydroamination reactions of hydroxylamine and hydrazine derivatives

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Article information


Submitted
06 Jun 2013
Accepted
10 Sep 2013
First published
17 Sep 2013

Org. Biomol. Chem., 2013,11, 7039-7050
Article type
Emerging Area

Recent developments in Cope-type hydroamination reactions of hydroxylamine and hydrazine derivatives

A. M. Beauchemin, Org. Biomol. Chem., 2013, 11, 7039
DOI: 10.1039/C3OB41172A

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