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Issue 41, 2013
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Recent developments in Cope-type hydroamination reactions of hydroxylamine and hydrazine derivatives

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Abstract

Cope-type hydroaminations are versatile for the direct amination of alkenes, alkynes and allenes using hydroxylamines and hydrazine derivatives. These reactions occur via a concerted, 5-membered cyclic transition state that is the microscopic reverse of the Cope elimination. This article focuses on recent developments, including intermolecular variants, directed reactions, and asymmetric variants using aldehydes as tethering catalysts, and their applications in target-oriented synthesis.

Graphical abstract: Recent developments in Cope-type hydroamination reactions of hydroxylamine and hydrazine derivatives

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Publication details

The article was received on 06 Jun 2013, accepted on 10 Sep 2013 and first published on 17 Sep 2013


Article type: Emerging Area
DOI: 10.1039/C3OB41172A
Org. Biomol. Chem., 2013,11, 7039-7050

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    Recent developments in Cope-type hydroamination reactions of hydroxylamine and hydrazine derivatives

    A. M. Beauchemin, Org. Biomol. Chem., 2013, 11, 7039
    DOI: 10.1039/C3OB41172A

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