Issue 27, 2013
From the journal:

Organic & Biomolecular Chemistry

Aerobic C–H amination of tetrahydrocarbazole derivatives via photochemically generated hydroperoxides†

Naeem Gulzara  and  Martin Klussmann*a  

* Corresponding authors

a Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany
E-mail: klusi@mpi-muelheim.mpg.de
Fax: (+49) 208-306-2980
Tel: (+49) 208-306-2453

Abstract

A Brønsted acid catalyzed C–H functionalization via Intermediate PeroxideS (CHIPS), generated photochemically, allows the oxidative coupling of indole derivatives with a variety of nitrogen nucleophiles. The reaction can be performed in one pot and requires only visible light, elemental oxygen, a Brønsted acid and a photosensitizer. The method can be applied to an efficient synthesis of some biologically active compounds.

Graphical abstract: Aerobic C–H amination of tetrahydrocarbazole derivatives via photochemically generated hydroperoxides

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Article information

DOI
https://doi.org/10.1039/C3OB40919H
Article type
Paper
Submitted
20 Mar 2013
Accepted
13 May 2013
First published
14 May 2013
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2013,11, 4516-4520

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Aerobic C–H amination of tetrahydrocarbazole derivatives via photochemically generated hydroperoxides

N. Gulzar and M. Klussmann, Org. Biomol. Chem., 2013, 11, 4516 DOI: 10.1039/C3OB40919H

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