Issue 34, 2013
From the journal:

Organic & Biomolecular Chemistry

Potential use of synthetic α-galactosyl-containing glycotopes of the parasite Trypanosoma cruzi as diagnostic antigens for Chagas disease†

Roger A. Ashmus,a   Nathaniel S. Schocker,a   Yanira Cordero-Mendoza,b   Alexandre F. Marques,b   Erika Y. Monroy,a   Andrew Pardo,a   Luis Izquierdo,c   Montserrat Gállego,c   Joaquim Gascon,c   Igor C. Almeida*b  and  Katja Michael*a  

* Corresponding authors

a Department of Chemistry, University of Texas at El Paso, El Paso, TX 79968, USA
E-mail: kmichael@utep.edu

b Border Biomedical Research Center, Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968, USA
E-mail: icalmeida@utep.edu

c Barcelona Centre for International Health Research, CRESIB, Hospital Clinic – Universitat de Barcelona, 08036 Barcelona, Spain

Abstract

A synthetic glycoarray containing non-reducing α-galactopyranosyl moieties related to mucin O-glycans of the parasite Trypanosoma cruzi was evaluated by a chemiluminescent enzyme-linked immunosorbent assay with sera from patients with chronic Chagas disease. Our data revealed the disaccharide Galα(1,3)Galβ as the immunodominant glycotope, which may eventually be employed as a diagnostic antigen for Chagas disease.

Graphical abstract: Potential use of synthetic α-galactosyl-containing glycotopes of the parasite Trypanosoma cruzi as diagnostic antigens for Chagas disease

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3OB40887F
Article type
Communication
Submitted
30 Apr 2013
Accepted
02 Jul 2013
First published
02 Jul 2013

Org. Biomol. Chem., 2013,11, 5579-5583

Permissions

Request permissions

Potential use of synthetic α-galactosyl-containing glycotopes of the parasite Trypanosoma cruzi as diagnostic antigens for Chagas disease

R. A. Ashmus, N. S. Schocker, Y. Cordero-Mendoza, A. F. Marques, E. Y. Monroy, A. Pardo, L. Izquierdo, M. Gállego, J. Gascon, I. C. Almeida and K. Michael, Org. Biomol. Chem., 2013, 11, 5579 DOI: 10.1039/C3OB40887F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements