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Issue 28, 2013
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Copper-catalyzed oxidative condensation of α-oxocarboxylic acids with formamides: synthesis of α-ketoamides

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Abstract

A copper-catalyzed coupling of α-oxocarboxylic acids with formamides is reported. This simple method provides a practical approach toward the synthesis of α-ketoamides with a variety of functional groups. Mechanistic studies have shown that the reaction proceeded via a radical process and 13C-labeled experiments proved that the amide carbon in the products comes from the corresponding carboxylic acid, not from the DMF.

Graphical abstract: Copper-catalyzed oxidative condensation of α-oxocarboxylic acids with formamides: synthesis of α-ketoamides

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Publication details

The article was received on 18 Apr 2013, accepted on 22 May 2013 and first published on 23 May 2013


Article type: Communication
DOI: 10.1039/C3OB40787J
Org. Biomol. Chem., 2013,11, 4573-4576

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    Copper-catalyzed oxidative condensation of α-oxocarboxylic acids with formamides: synthesis of α-ketoamides

    H. Wang, L. Guo and X. Duan, Org. Biomol. Chem., 2013, 11, 4573
    DOI: 10.1039/C3OB40787J

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