Issue 20, 2013
From the journal:

Organic & Biomolecular Chemistry

Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner–Wadsworth–Emmons olefination/cyclisation†

Calum W. Muir,a   Alan R. Kennedy,a   Joanna M. Redmondb  and  Allan J. B. Watson*a  

* Corresponding authors

a Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, Thomas Graham Building, 295 Cathedral Street, Glasgow, UK
E-mail: allan.watson.100@strath.ac.uk
Fax: +44 (0)141 548 4822
Tel: +44 (0)141 548 2439

b GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK

Abstract

4H-Quinolizin-4-ones are a unique class of heterocycle with valuable physicochemical properties and which are emerging as key pharmacophores for a range of biological targets. A tandem Horner–Wadsworth–Emmons olefination/cyclisation method has been developed to allow facile access to substituted 4H-quinolizin-4-ones encoded with a range of functional groups.

Graphical abstract: Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner–Wadsworth–Emmons olefination/cyclisation

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Article information

DOI
https://doi.org/10.1039/C3OB40578H
Article type
Paper
Submitted
22 Mar 2013
Accepted
25 Mar 2013
First published
26 Mar 2013

Org. Biomol. Chem., 2013,11, 3337-3340

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Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner–Wadsworth–Emmons olefination/cyclisation

C. W. Muir, A. R. Kennedy, J. M. Redmond and A. J. B. Watson, Org. Biomol. Chem., 2013, 11, 3337 DOI: 10.1039/C3OB40578H

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