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Issue 21, 2013
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Towards a dynamic covalent molecular switch: substituent effects in chalcone/flavanone isomerism

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Abstract

Chalcone/flavanone interconversion occurs facilely under aqueous alkaline conditions making it a promising scaffold for the development of a covalent molecular switch. In this study, a single methoxy substituent is shown to have a significant impact on the equilibrium dynamics of this reaction; this impact is dependent on the site of substitution.

Graphical abstract: Towards a dynamic covalent molecular switch: substituent effects in chalcone/flavanone isomerism

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Publication details

The article was received on 07 Mar 2013, accepted on 12 Mar 2013 and first published on 18 Mar 2013


Article type: Communication
DOI: 10.1039/C3OB40467F
Citation: Org. Biomol. Chem., 2013,11, 3421-3423

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    Towards a dynamic covalent molecular switch: substituent effects in chalcone/flavanone isomerism

    J. Mai, E. Hoxha, C. E. Morton, B. M. Muller and M. J. Adler, Org. Biomol. Chem., 2013, 11, 3421
    DOI: 10.1039/C3OB40467F

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