Issue 18, 2013

Synthesis of 2-amino-imidazo[4,5-b]pyridines

Abstract

The C2 amination of imidazo[4,5-b]pyridines was accomplished through C2 halogenation followed by substitution (SNAr) with functionalized primary and secondary amines. This regioselective sequence is operationally simple and provides an easy access to derivatives of protected imidazo[4,5-b]pyridines.

Graphical abstract: Synthesis of 2-amino-imidazo[4,5-b]pyridines

Supplementary files

Article information

Article type
Paper
Submitted
27 Feb 2013
Accepted
14 Mar 2013
First published
14 Mar 2013

Org. Biomol. Chem., 2013,11, 3064-3072

Synthesis of 2-amino-imidazo[4,5-b]pyridines

A. J. Rosenberg, T. M. Williams, A. J. Jordan and D. A. Clark, Org. Biomol. Chem., 2013, 11, 3064 DOI: 10.1039/C3OB40413G

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