Issue 25, 2013
From the journal:

Organic & Biomolecular Chemistry

Aerobic oxidation of indole carbinols using Fe(NO3)3·9H2O/TEMPO/NaCl as catalysts†

Jinxian Liua  and  Shengming Ma*ab  

* Corresponding authors

a Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University, 3663 North Zhongshan Lu, Shanghai 200062, P. R. China
E-mail: masm@sioc.ac.cn
Fax: (+86)-21-6260-9305

b Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, P. R. China

Abstract

A practical aerobic oxidation of indole carbinols using Fe(NO3)3·9H2O/TEMPO/NaCl in DCE at room temperature and atmospheric pressure of oxygen affording aldehydes or ketones in good to excellent yields was developed. Furthermore, when using the industrially favored solvent toluene instead of DCE and air instead of pure oxygen, this protocol also works smoothly, demonstrating its high potential for possible industrial application.

Graphical abstract: Aerobic oxidation of indole carbinols using Fe(NO3)3·9H2O/TEMPO/NaCl as catalysts

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Article information

DOI
https://doi.org/10.1039/C3OB40226F
Article type
Paper
Submitted
01 Feb 2013
Accepted
13 Apr 2013
First published
16 Apr 2013

Org. Biomol. Chem., 2013,11, 4186-4193

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Aerobic oxidation of indole carbinols using Fe(NO3)3·9H2O/TEMPO/NaCl as catalysts

J. Liu and S. Ma, Org. Biomol. Chem., 2013, 11, 4186 DOI: 10.1039/C3OB40226F

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