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Issue 26, 2013
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Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase

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Abstract

Human neutrophil elastase (HNE) is a serine protease implicated in the pathogenesis of acute and chronic inflammatory disease. Here a series of, internally quenched, single fluorophore fluorescent reporters were synthesised that allowed the rapid, highly specific and sensitive analysis of HNE activity over closely related proteases.

Graphical abstract: Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase

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Article information


Submitted
30 Jan 2013
Accepted
29 Apr 2013
First published
01 May 2013

Org. Biomol. Chem., 2013,11, 4414-4418
Article type
Paper

Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase

N. Avlonitis, M. Debunne, T. Aslam, N. McDonald, C. Haslett, K. Dhaliwal and M. Bradley, Org. Biomol. Chem., 2013, 11, 4414
DOI: 10.1039/C3OB40212F

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