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Issue 6, 2013
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Development of a benzophenone and alkyne functionalised trehalose probe to study trehalose dimycolate binding proteins

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Abstract

Trehalose dimycolates (TDMs) are the most abundant glycolipids found in the cell wall of Mycobacterium tuberculosis (M. tb). TDMs play an important role in the pathogenesis of M. tb yet the only known receptor for TDM is the macrophage inducible C-type lectin (mincle). To understand more about the interaction of TDMs with immune cells, affinity based proteome profiling (AfBPP) can be used to determine receptors that bind TDMs. To this end, we present the synthesis of the first AfBPP-TDM probe and report on its ability to activate macrophages. By doing so, we establish that the AfBPP-TDM probe appears to be a suitable substrate for future proteomic profiling experiments.

Graphical abstract: Development of a benzophenone and alkyne functionalised trehalose probe to study trehalose dimycolate binding proteins

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Supplementary files

Article information


Submitted
20 Nov 2012
Accepted
06 Dec 2012
First published
11 Dec 2012

Org. Biomol. Chem., 2013,11, 881-885
Article type
Communication

Development of a benzophenone and alkyne functionalised trehalose probe to study trehalose dimycolate binding proteins

A. A. Khan, F. Kamena, M. S. M. Timmer and B. L. Stocker, Org. Biomol. Chem., 2013, 11, 881
DOI: 10.1039/C2OB27257A

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