Issue 16, 2013
From the journal:

Organic & Biomolecular Chemistry

A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen†

Chikako Komeda,a   Atsushi Ikeda,*a   Jun-ichi Kikuchi,a   Norihiro Ishida-Kitagawa,b   Hisashi Tatebe,b   Kazuhiro Shiozakib  and  Motofusa Akiyamaac  

* Corresponding authors

a Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan
E-mail: aikeda@ms.naist.jp
Fax: +81 743 72 6099
Tel: +81 743 72 6091

b Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan

c Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 113-8551, Japan

Abstract

To circumvent the limitations of polyethylene glycol (PEG) modified carriers, a photo-triggerable liposome was prepared which was modified by cholesterol derivatives via a cleavable vinyl ether linkage so that the PEGylated coating can be efficiently removed by a photoactivated fullerene. After the photocleavage of the PEG moiety, the intracellular uptake of the photo-triggerable liposome improved.

Graphical abstract: A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen

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Article information

DOI
https://doi.org/10.1039/C2OB27199K
Article type
Communication
Submitted
12 Nov 2012
Accepted
19 Dec 2012
First published
20 Dec 2012

Org. Biomol. Chem., 2013,11, 2567-2570

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A photo-triggerable drug carrier based on cleavage of PEG lipids by photosensitiser-generated reactive singlet oxygen

C. Komeda, A. Ikeda, J. Kikuchi, N. Ishida-Kitagawa, H. Tatebe, K. Shiozaki and M. Akiyama, Org. Biomol. Chem., 2013, 11, 2567 DOI: 10.1039/C2OB27199K

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