Issue 5, 2013
From the journal:

Organic & Biomolecular Chemistry

New 2,3-diaminopropionic acidinhibitors of AGE and ALE formation

Nicolas Audic,a   Guy Potiera  and  N. André Sasaki*ab  

* Corresponding authors

a Pharmamens, 9 avenue Théophile Gautier, 75016 Paris, France

b Laboratoire des Glucides, CNRS FRE 3517, UFR de Pharmacie, Université de Picardie Jules Verne, 1 rue des Louvels, 80037 Amiens Cedex 1, France
E-mail: andre.sasaki@u-picardie.fr
Tel: +33 (0)3 22 82 74 98

Abstract

Novel 2,3-diaminopropionic acid-based molecules were synthesised and tested successfully as glyoxal/methylglyoxal scavengers and as AGE inhibitors. Addition of an 8-hydroxyquinoline moiety led to an increase of the overall activity. The compounds tested in this study were also proved to be efficient in trapping ALE precursor malondialdehyde.

Graphical abstract: New 2,3-diaminopropionic acid inhibitors of AGE and ALE formation

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Article information

DOI
https://doi.org/10.1039/C2OB27084F
Article type
Paper
Submitted
25 Oct 2012
Accepted
30 Nov 2012
First published
03 Dec 2012

Org. Biomol. Chem., 2013,11, 773-780

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New 2,3-diaminopropionic acid inhibitors of AGE and ALE formation

N. Audic, G. Potier and N. A. Sasaki, Org. Biomol. Chem., 2013, 11, 773 DOI: 10.1039/C2OB27084F

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