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Issue 14, 2013
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Bioconjugation on cube-octameric silsesquioxanes

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Abstract

Small, compact, and highly symmetric cube-octameric silsesquioxanes have recently attracted increased attention as scaffolds for tailor-made bioconjugates. The expanded arsenal of effective conjugation methods (CuAAC, TEC, oxime ligation) allows one to decorate these nanoparticles bearing up to eight addressable organic substituents, with a wide range of biorelevant ligands, among them carbohydrates, peptides, miniproteins, reporter molecules, and rare-earth chelates. Low toxicity of COSS-based molecules combined with solubility in aqueous systems and half-life sufficient for in vivo studies make these structures attractive targets for a number of applications, among them drug delivery, tumor diagnostics and therapy.

Graphical abstract: Bioconjugation on cube-octameric silsesquioxanes

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Publication details

The article was received on 14 Sep 2012, accepted on 23 Oct 2012 and first published on 24 Oct 2012


Article type: Perspective
DOI: 10.1039/C2OB26807H
Org. Biomol. Chem., 2013,11, 2224-2236

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    Bioconjugation on cube-octameric silsesquioxanes

    S. Fabritz, S. Hörner, O. Avrutina and H. Kolmar, Org. Biomol. Chem., 2013, 11, 2224
    DOI: 10.1039/C2OB26807H

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