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Issue 2, 2013
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Stereoselective synthesis of cyclic amino acidsvia asymmetric phase-transfer catalytic alkylation

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Abstract

An asymmetric synthesis of cyclic amino acids having piperidine and azepane core structures was realized starting from readily available glycine and alanine esters by combination of phase-transfer catalyzed asymmetric alkylation and subsequent reductive amination.

Graphical abstract: Stereoselective synthesis of cyclic amino acids via asymmetric phase-transfer catalytic alkylation

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Supplementary files

Article information


Submitted
10 Sep 2012
Accepted
04 Oct 2012
First published
05 Oct 2012

Org. Biomol. Chem., 2013,11, 271-278
Article type
Paper

Stereoselective synthesis of cyclic amino acids via asymmetric phase-transfer catalytic alkylation

T. Kano, T. Kumano, R. Sakamoto and K. Maruoka, Org. Biomol. Chem., 2013, 11, 271
DOI: 10.1039/C2OB26778K

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