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Issue 4, 2014
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Photocleavage control of nucleated DNA nanosystems – the influence of surface strand sterics

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Abstract

We use sterically inaccessible ‘seed’ strands, released from a surface into solution by photocleavage to initiate a nucleated DNA polymerization reaction. We demonstrate control of the quantity of ‘seed’ release and that hairpin steric protection of the ‘seed’ leads to less ‘leaky’ surfaces. This polymerization is a model system for surface-photocleavage initiation of sub-stoichiometric reaction cascades; these cascades should find use as a component of labs-on-chips capable of bioanalytical and DNA-computing tasks.

Graphical abstract: Photocleavage control of nucleated DNA nanosystems – the influence of surface strand sterics

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Article information


Submitted
04 Nov 2013
Accepted
17 Dec 2013
First published
20 Dec 2013

Nanoscale, 2014,6, 2094-2096
Article type
Communication
Author version available

Photocleavage control of nucleated DNA nanosystems – the influence of surface strand sterics

M. Hanna, M. Munshi, N. A. Kedzierski, P. N. Chung, T. Huang, A. K. Mok and P. S. Lukeman, Nanoscale, 2014, 6, 2094
DOI: 10.1039/C3NR05875A

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