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Issue 21, 2013
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Point-of-care nucleic acid detection using nanotechnology

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Recent developments in nanotechnology have led to significant advancements in point-of-care (POC) nucleic acid detection. The ability to sense DNA and RNA in a portable format leads to important applications for a range of settings, from on-site detection in the field to bedside diagnostics, in both developing and developed countries. We review recent innovations in three key process components for nucleic acid detection: sample preparation, target amplification, and read-out modalities. We discuss how the advancements realized by nanotechnology are making POC nucleic acid detection increasingly applicable for decentralized and accessible testing, in particular for the developing world.

Graphical abstract: Point-of-care nucleic acid detection using nanotechnology

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Publication details

The article was received on 01 Aug 2013, accepted on 19 Aug 2013 and first published on 27 Aug 2013

Article type: Feature Article
DOI: 10.1039/C3NR04015A
Nanoscale, 2013,5, 10141-10154

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    Point-of-care nucleic acid detection using nanotechnology

    M. R. Hartman, R. C. H. Ruiz, S. Hamada, C. Xu, K. G. Yancey, Y. Yu, W. Han and D. Luo, Nanoscale, 2013, 5, 10141
    DOI: 10.1039/C3NR04015A

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