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Issue 22, 2013
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Comprehensive characterizations of nanoparticle biodistribution following systemic injection in mice

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Abstract

Various nanoparticle (NP) properties such as shape and surface charge have been studied in an attempt to enhance the efficacy of NPs in biomedical applications. When trying to undermine the precise biodistribution of NPs within the target organs, the analytical method becomes the determining factor in measuring the precise quantity of distributed NPs. High performance liquid chromatography (HPLC) represents a more powerful tool in quantifying NP biodistribution compared to conventional analytical methods such as an in vivo imaging system (IVIS). This, in part, is due to better curve linearity offered by HPLC than IVIS. Furthermore, HPLC enables us to fully analyze each gram of NPs present in the organs without compromising the signals and the depth-related sensitivity as is the case in IVIS measurements. In addition, we found that changing physiological conditions improved large NP (200–500 nm) distribution in brain tissue. These results reveal the importance of selecting analytic tools and physiological environment when characterizing NP biodistribution for future nanoscale toxicology, therapeutics and diagnostics.

Graphical abstract: Comprehensive characterizations of nanoparticle biodistribution following systemic injection in mice

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Supplementary files

Article information


Submitted
30 Jul 2013
Accepted
03 Sep 2013
First published
06 Sep 2013

Nanoscale, 2013,5, 11079-11086
Article type
Paper

Comprehensive characterizations of nanoparticle biodistribution following systemic injection in mice

W. Liao, H. Li, M. Chang, A. C. L. Tang, A. S. Hoffman and P. C. H. Hsieh, Nanoscale, 2013, 5, 11079
DOI: 10.1039/C3NR03954D

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