Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles

Ronnie H. Fang; Che-Ming J. Hu; Kevin N. H. Chen; Brian T. Luk; Cody W. Carpenter; Weiwei Gao; Shulin Li; Dong-Er Zhang; Weiyue Lu; Liangfang Zhang

doi:10.1039/C3NR03064D

Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles†

Ronnie H. Fang,^ab Che-Ming J. Hu,^ab Kevin N. H. Chen,^a Brian T. Luk,^bc Cody W. Carpenter,^a Weiwei Gao,^ab Shulin Li,^d Dong-Er Zhang,^b Weiyue Lu^e and Liangfang Zhang*^ab

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* Corresponding authors

^a Department of NanoEngineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
E-mail: zhang@ucsd.edu
Tel: +1-858-246-0999

^b Moores Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA

^c Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA

^d Department of Pediatric Research, MD Anderson Cancer Center, Houston, TX 77030, USA

^e Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, School of Pharmacy, Fudan University, Shanghai 201203, China

Abstract

RBC membrane-cloaked polymeric nanoparticles represent an emerging nanocarrier platform with extended circulation in vivo. A lipid-insertion method is employed to functionalize these nanoparticles without the need for direct chemical conjugation. Insertion of both folate and the nucleolin-targeting aptamer AS1411 shows receptor-specific targeting against model cancer cell lines.

Nanoscale

Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles†

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Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles

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