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Issue 20, 2013
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Janus nanogels of PEGylated Taxol and PLGA–PEG–PLGA copolymer for cancer therapy

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Abstract

Nanogels are promising carriers for the delivery of anti-cancer drugs for cancer therapy. We report in this study on a Janus nanogel system formed by mixing a prodrug of Taxol (PEGylated Taxol) and a copolymer of PLGA–PEG–PLGA. The Janus nanogels have good stability over months in aqueous solutions and the freeze-dried powder of nanogels can be re-dispersed instantly in aqueous solutions. The Janus nanogels show an enhanced inhibition effect on tumor growth in a mice breast cancer model probably due to the enhanced uptake of the nano-sized materials by the EPR effect. What is more, the nanogels can also serve as physical carriers to co-deliver other anti-cancer drugs such as doxorubicin to further improve the anti-cancer efficacy. The results obtained from H&E staining and TUNEL assay also support the observation of tumor growth inhibition. These results suggest the potential of this novel delivery system for cancer therapy.

Graphical abstract: Janus nanogels of PEGylated Taxol and PLGA–PEG–PLGA copolymer for cancer therapy

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Supplementary files

Article information


Submitted
06 Jun 2013
Accepted
31 Jul 2013
First published
08 Aug 2013

Nanoscale, 2013,5, 9902-9907
Article type
Paper

Janus nanogels of PEGylated Taxol and PLGA–PEG–PLGA copolymer for cancer therapy

J. Wei, H. Wang, M. Zhu, D. Ding, D. Li, Z. Yin, L. Wang and Z. Yang, Nanoscale, 2013, 5, 9902
DOI: 10.1039/C3NR02937A

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