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Issue 10, 2013
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Improving the understanding of oligonucleotidenanoparticle conjugates using DNA-binding fluorophores

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Abstract

A novel fluorescent-based method for characterisation of oligonucleotidenanoparticle conjugates (ONPCs) is reported. We exploit the ability of the double-stranded DNA-binding dye, SYBR Green I, to develop a powerful analytical tool to investigate the melting properties and hybridisation behavior of ONPCs as well as their corresponding DNA-mediated assemblies.

Graphical abstract: Improving the understanding of oligonucleotide–nanoparticle conjugates using DNA-binding fluorophores

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Publication details

The article was received on 08 Mar 2013, accepted on 04 Apr 2013 and first published on 10 Apr 2013


Article type: Communication
DOI: 10.1039/C3NR01197F
Citation: Nanoscale, 2013,5, 4166-4170

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    Improving the understanding of oligonucleotidenanoparticle conjugates using DNA-binding fluorophores

    L. Guerrini, L. Barrett, J. A. Dougan, K. Faulds and D. Graham, Nanoscale, 2013, 5, 4166
    DOI: 10.1039/C3NR01197F

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