Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 1, 2013
Previous Article Next Article

Upconversion nanoparticles and their composite nanostructures for biomedical imaging and cancer therapy

Author affiliations

Abstract

Upconversion nanoparticles (UCNPs), particularly lanthanide-doped nanocrystals, which emit high energy photons under excitation by the near-infrared (NIR) light, have found potential applications in many different fields, including biomedicine. Compared with traditional down-conversion fluorescence imaging, the NIR light excited upconversion luminescence (UCL) imaging relying on UCNPs exhibits improved tissue penetration depth, higher photochemical stability, and is free of auto-fluorescence background, which promises biomedical imaging with high sensitivity. On the other hand, the unique upconversion process of UCNPs may be utilized to activate photosensitive therapeutic agents for applications in cancer treatment. Moreover, the integration of UCNPs with other functional nanostructures could result in the obtained nanocomposites having highly enriched functionalities, useful in imaging-guided cancer therapies. This review article will focus on the biomedical imaging and cancer therapy applications of UCNPs and their nanocomposites, and discuss recent advances and future prospects in this emerging field.

Graphical abstract: Upconversion nanoparticles and their composite nanostructures for biomedical imaging and cancer therapy

Back to tab navigation

Article information


Submitted
16 Aug 2012
Accepted
08 Oct 2012
First published
10 Oct 2012

Nanoscale, 2013,5, 23-37
Article type
Review Article

Upconversion nanoparticles and their composite nanostructures for biomedical imaging and cancer therapy

L. Cheng, C. Wang and Z. Liu, Nanoscale, 2013, 5, 23
DOI: 10.1039/C2NR32311G

Social activity

Search articles by author

Spotlight

Advertisements