Copper(ii) and zinc(ii) dependent effects on Aβ42 aggregation: a CD, Th-T and SFM study†
Abstract
Aβ aggregation is a central event in Alzheimer's disease (AD). In vitro evidence indicates that Aβ aggregation and fibrillogenesis are significantly influenced by the employed experimental conditions. Indeed, although it is widely established that metal ions, such as copper and zinc, have significant effects on the Aβ aggregation process, their actual role in Aβ fibrillogenesis is still debated. In this work the effects of a molar excess of zinc(II) and/or copper(II) ions on the Aβ42 aggregation process and the morphology of the resultant aggregates have been compared in samples exhibiting different initial conformations.