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Issue 10, 2013
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An intrinsically fluorescent glycoligand for direct imaging of ligand trafficking in artificial and living cell systems

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Abstract

Glycoligands, sugar-based molecules able to complex metal cations, constitute a new class of molecules with great potential for biological and biochemical applications. To analyze their behaviour in a biological environment, we have synthesized an intrinsically fluorescent glycoligand and analyzed its trafficking in both living (U937 human cancer cells) and artificial (giant unilamellar vesicles) cell systems. We have found that this ligand has moderate cytotoxicity accompanied by specific accumulation in both living and reconstituted membranes, which it can cross to reach inner compartments.

Graphical abstract: An intrinsically fluorescent glycoligand for direct imaging of ligand trafficking in artificial and living cell systems

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Article information


Submitted
10 Apr 2013
Accepted
08 Jul 2013
First published
08 Jul 2013

New J. Chem., 2013,37, 3030-3034
Article type
Paper

An intrinsically fluorescent glycoligand for direct imaging of ligand trafficking in artificial and living cell systems

L. Garcia, M. Lazzaretti, A. Diguet, F. Mussi, F. Bisceglie, J. Xie, G. Pelosi, A. Buschini, D. Baigl and C. Policar, New J. Chem., 2013, 37, 3030
DOI: 10.1039/C3NJ00380A

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