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Issue 10, 2013
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Analytical methods for copper, zinc and iron quantification in mammalian cells

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Abstract

Highly complex analytical methods with different accuracies of measurement, reproducibilities and ease of analyses are currently being used to quantify metals in cellular media and tissue samples. In this review, the analytical methods commonly used for iron, copper and zinc quantification in mammalian cells are presented and discussed. Herein, we present a literature survey of the most commonly found concentrations of these metals in various mammalian cells in culture and tissues. The aim of this review is to help researchers in metallomic-related areas identify the method that best suits their needs for the accurate quantification of these metals in cells. This accuracy goes beyond simple knowledge of the limit of detection of each technique and needs to be evaluated through comparisons with similar previous studies.

Graphical abstract: Analytical methods for copper, zinc and iron quantification in mammalian cells

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Publication details

The article was received on 03 May 2013, accepted on 12 Jul 2013 and first published on 12 Jul 2013


Article type: Critical Review
DOI: 10.1039/C3MT00136A
Citation: Metallomics, 2013,5, 1336-1345
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    Analytical methods for copper, zinc and iron quantification in mammalian cells

    G. Cerchiaro, T. M. Manieri and F. R. Bertuchi, Metallomics, 2013, 5, 1336
    DOI: 10.1039/C3MT00136A

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