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Issue 10, 2013
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Synthesis of [18F]fluoro-pivalic acid: an improved PET imaging probe for the fatty acid synthesis pathway in tumours

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Abstract

[18F]Fluoro-pivalic acid ([18F]FPIA), an analogue of [18F]fluoroacetate bearing a dimethyl moiety on C-2, has been radiosynthesised and evaluated in vivo. [18F]FPIA has high tumour uptake and, unlike [18F]fluoroacetate, does not defluorinate.

Graphical abstract: Synthesis of [18F]fluoro-pivalic acid: an improved PET imaging probe for the fatty acid synthesis pathway in tumours

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The article was received on 13 Jun 2013, accepted on 16 Jul 2013 and first published on 18 Jul 2013


Article type: Concise Article
DOI: 10.1039/C3MD00169E
Med. Chem. Commun., 2013,4, 1350-1353

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    Synthesis of [18F]fluoro-pivalic acid: an improved PET imaging probe for the fatty acid synthesis pathway in tumours

    F. Pisaneschi, T. H. Witney, L. Iddon and E. O. Aboagye, Med. Chem. Commun., 2013, 4, 1350
    DOI: 10.1039/C3MD00169E

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