Issue 10, 2013

Microwave-assisted synthesis of N-heterocycles in medicinal chemistry

Abstract

The syntheses of almost all N-heterocycles have now been successfully performed under microwave irradiation and have provided significant improvements in the reaction time and efficiency. The peculiar properties of dielectric heating give it the ability to strongly promote cyclocondensation, cycloaddition and selective N-heterocycle functionalisation and it has, therefore, very much caught the attention of the medicinal chemistry community. In this work, we present an overview of recent literature and technical advances in this research field with the aim of providing insight into the applications of microwave-assisted synthesis in the preparation of the main drug categories that contain N-heterocycle scaffolds.

Graphical abstract: Microwave-assisted synthesis of N-heterocycles in medicinal chemistry

Article information

Article type
Review Article
Submitted
02 Jun 2013
Accepted
07 Aug 2013
First published
08 Aug 2013

Med. Chem. Commun., 2013,4, 1323-1343

Microwave-assisted synthesis of N-heterocycles in medicinal chemistry

D. Garella, E. Borretto, A. Di Stilo, K. Martina, G. Cravotto and P. Cintas, Med. Chem. Commun., 2013, 4, 1323 DOI: 10.1039/C3MD00152K

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