Issue 9, 2013

Peptides: minimal drug surrogates to interrogate and interfere with protein function

Abstract

The interactome in normal and disease cells is a key area for study and therapeutic targeting, yet few molecules have been developed that can interfere with proteinprotein interactions within cells. A variety of options are being examined to target proteinprotein interfaces in simple and in multi protein complexes. The work of Hamilton and colleagues has developed approaches to the synthesis of proteomimetics for this purpose and thus recognized novel scaffolds can be critical reagents to protein targets. In this short report, we have outlined two of our own molecular biology approaches to specific peptide isolation targeting protein interfaces for peptide design, with the goal being eventual therapeutic intervention.

Graphical abstract: Peptides : minimal drug surrogates to interrogate and interfere with protein function

Article information

Article type
Review Article
Submitted
20 May 2013
Accepted
10 Jul 2013
First published
19 Jul 2013

Med. Chem. Commun., 2013,4, 1218-1221

Peptides: minimal drug surrogates to interrogate and interfere with protein function

A. Cruz-Migoni, N. Fuentes-Fernandez and T. H. Rabbitts, Med. Chem. Commun., 2013, 4, 1218 DOI: 10.1039/C3MD00142C

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