Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 9, 2013
Previous Article Next Article

Peptides: minimal drug surrogates to interrogate and interfere with protein function

Author affiliations

Abstract

The interactome in normal and disease cells is a key area for study and therapeutic targeting, yet few molecules have been developed that can interfere with proteinprotein interactions within cells. A variety of options are being examined to target proteinprotein interfaces in simple and in multi protein complexes. The work of Hamilton and colleagues has developed approaches to the synthesis of proteomimetics for this purpose and thus recognized novel scaffolds can be critical reagents to protein targets. In this short report, we have outlined two of our own molecular biology approaches to specific peptide isolation targeting protein interfaces for peptide design, with the goal being eventual therapeutic intervention.

Graphical abstract: Peptides : minimal drug surrogates to interrogate and interfere with protein function

Back to tab navigation

Article information


Submitted
20 May 2013
Accepted
10 Jul 2013
First published
19 Jul 2013

Med. Chem. Commun., 2013,4, 1218-1221
Article type
Review Article

Peptides: minimal drug surrogates to interrogate and interfere with protein function

A. Cruz-Migoni, N. Fuentes-Fernandez and T. H. Rabbitts, Med. Chem. Commun., 2013, 4, 1218
DOI: 10.1039/C3MD00142C

Search articles by author

Spotlight

Advertisements