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Issue 6, 2013
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Identification of a potent salicylic acid-based inhibitor of tyrosine phosphatase PTP1B

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Abstract

A screen of a library of diverse small-molecules against a subset of phosphatases identified 7b and 7c, which potently inhibit TC-PTP, PTPσ and PTP1B with no inhibition of PTP-LAR, PRL2 A/S, MKPX or papain. In CHO-IR cells these inhibitors effectively suppress PTP1B activity restoring the insulin receptor phosphorylation levels.

Graphical abstract: Identification of a potent salicylic acid-based inhibitor of tyrosine phosphatase PTP1B

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Publication details

The article was received on 08 Jan 2013, accepted on 07 May 2013 and first published on 10 May 2013


Article type: Concise Article
DOI: 10.1039/C3MD00011G
Citation: Med. Chem. Commun., 2013,4, 987-992

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    Identification of a potent salicylic acid-based inhibitor of tyrosine phosphatase PTP1B

    S. Haftchenary, D. P. Ball, I. Aubry, M. Landry, V. M. Shahani, S. Fletcher, B. D. G. Page, A. O. Jouk, M. L. Tremblay and P. T. Gunning, Med. Chem. Commun., 2013, 4, 987
    DOI: 10.1039/C3MD00011G

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