Issue 6, 2013

Identification of a potent salicylic acid-based inhibitor of tyrosine phosphatase PTP1B

Abstract

A screen of a library of diverse small-molecules against a subset of phosphatases identified 7b and 7c, which potently inhibit TC-PTP, PTPσ and PTP1B with no inhibition of PTP-LAR, PRL2 A/S, MKPX or papain. In CHO-IR cells these inhibitors effectively suppress PTP1B activity restoring the insulin receptor phosphorylation levels.

Graphical abstract: Identification of a potent salicylic acid-based inhibitor of tyrosine phosphatase PTP1B

Supplementary files

Article information

Article type
Concise Article
Submitted
08 Jan 2013
Accepted
07 May 2013
First published
10 May 2013

Med. Chem. Commun., 2013,4, 987-992

Identification of a potent salicylic acid-based inhibitor of tyrosine phosphatase PTP1B

S. Haftchenary, D. P. Ball, I. Aubry, M. Landry, V. M. Shahani, S. Fletcher, B. D. G. Page, A. O. Jouk, M. L. Tremblay and P. T. Gunning, Med. Chem. Commun., 2013, 4, 987 DOI: 10.1039/C3MD00011G

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