Jump to main content
Jump to site search

Issue 2, 2013
Previous Article Next Article

Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington's disease

Author affiliations

Abstract

The BBB-permeable trehalose derivative (TD-G6) was found to efficiently prevent the aggregation of polyQ in the transfected HEK293 cells. Furthermore, it was also found to significantly prolong lifespan, improve motor functions, and reduce the inclusion bodies in a transgenic mouse model (Tg R6/2), when given ad libitum.

Graphical abstract: Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington's disease

Back to tab navigation

Supplementary files

Article information


Submitted
02 May 2012
Accepted
19 Oct 2012
First published
22 Oct 2012

Med. Chem. Commun., 2013,4, 310-316
Article type
Concise Article

Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington's disease

J. Im, S. Kim, Y. Jeong, W. Kim, D. Lee, W. S. Lee, Y. Chang, K. Kim and S. Chung, Med. Chem. Commun., 2013, 4, 310
DOI: 10.1039/C2MD20112G

Search articles by author

Spotlight

Advertisements