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Issue 9, 2013
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Network representations and methods for the analysis of chemical and biochemical pathways

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Abstract

Systems biologists increasingly use network representations to investigate biochemical pathways and their dynamic behaviours. In this critical review, we discuss four commonly used network representations of chemical and biochemical pathways. We illustrate how some of these representations reduce network complexity but result in the ambiguous representation of biochemical pathways. We also examine the current theoretical approaches available to investigate the dynamic behaviour of chemical and biochemical networks. Finally, we describe how the critical chemical and biochemical pathways responsible for emergent dynamic behaviour can be identified using network mining and functional mapping approaches.

Graphical abstract: Network representations and methods for the analysis of chemical and biochemical pathways

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Article information


Submitted
05 Feb 2013
Accepted
19 Jun 2013
First published
19 Jun 2013

Mol. BioSyst., 2013,9, 2189-2200
Article type
Review Article

Network representations and methods for the analysis of chemical and biochemical pathways

C. I. Sandefur, M. Mincheva and S. Schnell, Mol. BioSyst., 2013, 9, 2189
DOI: 10.1039/C3MB70052F

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