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Issue 7, 2013
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Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models

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Abstract

Mathematical modelling is increasingly becoming an indispensable tool for the study of cellular processes, allowing their analysis in a systematic and comprehensive manner. In the vast majority of the cases, models focus on specific subsystems, and in particular describe either metabolism, gene expression or signal transduction. Integrated models that are able to span and interconnect these layers are, by contrast, rare as their construction and analysis face multiple challenges. Such methods, however, would represent extremely useful tools to understand cell behaviour, with application in distinct fields of biological and medical research. In particular, they could be useful tools to study genotype–phenotype mappings, and the way they are affected by specific conditions or perturbations. Here, we review existing computational approaches that integrate signalling, gene regulation and/or metabolism. We describe existing challenges, available methods and point at potentially useful strategies.

Graphical abstract: Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models

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Publication details

The article was received on 30 Oct 2012, accepted on 28 Feb 2013 and first published on 01 Mar 2013


Article type: Review Article
DOI: 10.1039/C3MB25489E
Mol. BioSyst., 2013,9, 1576-1583
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    Bridging the layers: towards integration of signal transduction, regulation and metabolism into mathematical models

    E. Gonçalves, J. Bucher, A. Ryll, J. Niklas, K. Mauch, S. Klamt, M. Rocha and J. Saez-Rodriguez, Mol. BioSyst., 2013, 9, 1576
    DOI: 10.1039/C3MB25489E

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