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Issue 24, 2013
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Actively transporting virus like analytes with optofluidics for rapid and ultrasensitive biodetection

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Abstract

Effective analyte delivery is essential to achieve rapid and sensitive biodetection systems. In this article, we present an actively controlled fluidic system integrated with a suspended plasmonic nanohole sensor to achieve superior analyte delivery efficiency and ultrafast sensor response, as compared to conventional fluidic systems. 70 nm sized virus like analyte solution is used to experimentally demonstrate the system performance improvements. Sensor response time is reduced by one order of magnitude as compared to the conventional methods. A seven orders of magnitude dynamic concentration range from 103 to 109 particles mL−1 is quantified, corresponding to a concentration window relevant to clinical diagnosis and drug screening. Our non-destructive detection system, by enabling efficient analyte delivery, fast sensing response and minimal sample volume, opens up opportunities for sensitive, rapid and real-time virus detection in infectious disease control and point-of-care applications.

Graphical abstract: Actively transporting virus like analytes with optofluidics for rapid and ultrasensitive biodetection

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Article information


Submitted
09 Jul 2013
Accepted
23 Sep 2013
First published
23 Sep 2013

Lab Chip, 2013,13, 4841-4847
Article type
Paper

Actively transporting virus like analytes with optofluidics for rapid and ultrasensitive biodetection

M. Huang, B. C. Galarreta, A. E. Cetin and H. Altug, Lab Chip, 2013, 13, 4841
DOI: 10.1039/C3LC50814E

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