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Issue 22, 2013
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A CMOS wireless biomolecular sensing system-on-chip based on polysilicon nanowire technology

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Abstract

As developments of modern societies, an on-field and personalized diagnosis has become important for disease prevention and proper treatment. To address this need, in this work, a polysilicon nanowire (poly-Si NW) based biosensor system-on-chip (bio-SSoC) is designed and fabricated by a 0.35 μm 2-Poly-4-Metal (2P4M) complementary metal-oxide-semiconductor (CMOS) process provided by a commercialized semiconductor foundry. Because of the advantages of CMOS system-on-chip (SoC) technologies, the poly-Si NW biosensor is integrated with a chopper differential-difference amplifier (DDA) based analog-front-end (AFE), a successive approximation analog-to-digital converter (SAR ADC), and a microcontroller to have better sensing capabilities than a traditional Si NW discrete measuring system. In addition, an on–off key (OOK) wireless transceiver is also integrated to form a wireless bio-SSoC technology. This is pioneering work to harness the momentum of CMOS integrated technology into emerging bio-diagnosis technologies. This integrated technology is experimentally examined to have a label-free and low-concentration biomolecular detection for both Hepatitis B Virus DNA (10 fM) and cardiac troponin I protein (3.2 pM). Based on this work, the implemented wireless bio-SSoC has demonstrated a good biomolecular sensing characteristic and a potential for low-cost and mobile applications. As a consequence, this developed technology can be a promising candidate for on-field and personalized applications in biomedical diagnosis.

Graphical abstract: A CMOS wireless biomolecular sensing system-on-chip based on polysilicon nanowire technology

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Supplementary files

Article information


Submitted
04 Jul 2013
Accepted
04 Sep 2013
First published
04 Sep 2013

Lab Chip, 2013,13, 4451-4459
Article type
Paper

A CMOS wireless biomolecular sensing system-on-chip based on polysilicon nanowire technology

C. Huang, Y. Huang, P. Yen, H. Tsai, H. Liao, Y. Juang, S. Lu and C. Lin, Lab Chip, 2013, 13, 4451
DOI: 10.1039/C3LC50798J

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