A novel approach to quantifying ciliary physiology: microfluidic mixing driven by a ciliated biological surface

Stephan Jonas; Elaine Zhou; Engin Deniz; Brendan Huang; Kenny Chandrasekera; Dipankan Bhattacharya; Yu Wu; Rong Fan; Thomas M. Deserno; Mustafa K. Khokha; Michael A. Choma

doi:10.1039/C3LC50571E

A novel approach to quantifying ciliary physiology: microfluidic mixing driven by a ciliated biological surface†

Stephan Jonas,*^ab Elaine Zhou,^ac Engin Deniz,^d Brendan Huang,^c Kenny Chandrasekera,^c Dipankan Bhattacharya,^d Yu Wu,^c Rong Fan,^c Thomas M. Deserno,^b Mustafa K. Khokha^de and Michael A. Choma*^acd

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^a Dept. of Diagnostic Radiology, Yale University, New Haven, CT, USA
E-mail: michael.choma@yale.edu
Tel: +1 (203) 785-2945

^b Dept. of Medical Informatics, RWTH Aachen University, Pauwelsstr. 30, Aachen, Germany
E-mail: sjonas@mi.rwth-aachen.de
Fax: +49 241 803388795
Tel: +49 241 8088795

^c Dept. of Biomedical Engineering, Yale University, New Haven, CT, USA

^d Dept. of Pediatrics, Yale University, New Haven, CT, USA

^e Dept. of Genetics, Yale University, New Haven, CT, USA

Abstract

From the lungs to the central nervous system, cilia-driven fluid flow plays a fundamental role in many facets of life. Yet, there are few quantitative methods for analysing the function of ciliated surfaces. Here, we report a novel microfluidic approach for quantifying the performance of a ciliated surface using mixing performance as an integrated readout.

Lab on a Chip

A novel approach to quantifying ciliary physiology: microfluidic mixing driven by a ciliated biological surface†

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A novel approach to quantifying ciliary physiology: microfluidic mixing driven by a ciliated biological surface

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