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Issue 18, 2013
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Single vesicle biochips for ultra-miniaturized nanoscale fluidics and single molecule bioscience

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Abstract

One of the major bottlenecks in the development of biochips is maintaining the structure and function of biomolecules when interfacing them with hard matter (glass, plastics, metals, etc.), a challenge that is exacerbated during miniaturization that inevitably increases the interface to volume ratio of these devices. Biochips based on immobilized vesicles circumvent this problem by encapsulating biomolecules in the protective environment of a lipid bilayer, thus minimizing interactions with hard surfaces. Here we review the development of biochips based on arrays of single nanoscale vesicles, their fabrication via controlled self-assembly, and their characterization using fluorescence microscopy. We also highlight their applications in selected fields such as nanofluidics and single molecule bioscience. Despite their great potential for improved biocompatibility, extreme miniaturization and high throughput, single vesicle biochips are still a niche technology that has yet to establish its commercial relevance.

Graphical abstract: Single vesicle biochips for ultra-miniaturized nanoscale fluidics and single molecule bioscience

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Publication details

The article was received on 18 Apr 2013, accepted on 04 Jun 2013 and first published on 16 Jul 2013


Article type: Critical Review
DOI: 10.1039/C3LC50492A
Lab Chip, 2013,13, 3613-3625

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    Single vesicle biochips for ultra-miniaturized nanoscale fluidics and single molecule bioscience

    A. L. Christensen, C. Lohr, S. M. Christensen and D. Stamou, Lab Chip, 2013, 13, 3613
    DOI: 10.1039/C3LC50492A

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