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Issue 13, 2013
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Double nanohole optical trapping: dynamics and protein-antibody co-trapping

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Abstract

A double nanohole in a metal film can optically trap nanoparticles such as polystyrene/silica spheres, encapsulated quantum dots and up-converting nanoparticles. Here we study the dynamics of trapped particles, showing a skewed distribution and low roll-off frequency that are indicative of Kramers-hopping at the nanoscale. Numerical simulations of trapped particles show a double-well potential normally found in Kramers-hopping systems, as well as providing quantitative agreement with the overall trapping potential. In addition, we demonstrate co-trapping of bovine serum albumin (BSA) with anti-BSA by sequential delivery in a microfluidic channel. This co-trapping opens up exciting possibilities for the study of protein interactions at the single particle level.

Graphical abstract: Double nanohole optical trapping: dynamics and protein-antibody co-trapping

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Article information


Submitted
02 Jan 2013
Accepted
13 Feb 2013
First published
18 Feb 2013

Lab Chip, 2013,13, 2563-2568
Article type
Paper

Double nanohole optical trapping: dynamics and protein-antibody co-trapping

A. Zehtabi-Oskuie, H. Jiang, B. R. Cyr, D. W. Rennehan, A. A. Al-Balushi and R. Gordon, Lab Chip, 2013, 13, 2563
DOI: 10.1039/C3LC00003F

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