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Issue 3, 2013
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An intravenous implantable glucose/dioxygen biofuel cell with modified flexible carbon fiber electrodes

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Abstract

An intravenous implantable glucose/dioxygen hybrid enzyme–Pt micro-biofuel cell (BFC) was investigated. In this miniaturized BFC, a flexible carbon fiber (FCF) microelectrode modified with neutral red redox mediator and glucose oxidase was used as the bioanode, and an FCF modified with platinum nanoparticles stabilized on PAMAM-G4 dendrimer was used as the cathode. In vitro experiments conducted using the BFC in a phosphate buffer solution (50 mmol L−1, pH = 7.2) and glucose (47 mmol L−1) showed high electrocatalytic performance with an open circuit voltage (OCV) of 400 mV, a maximum current density of 2700 μA cm−2 at 0.0 V and a maximum output power of 200 μW cm−2 at 250 mV. Under physiological conditions, glucose from rat blood is used as a fuel in anodic reactions and dissolved molecular oxygen is used as the oxidizing agent on the cathode. For in vivo experiments, the BFC was inserted into the jugular vein of a living rat (Rattus novergicus) using a catheter (internal diameter 0.5 mm). The power density of the implantable BFC was evaluated over a period of 24 h, and an OCV of 125 mV with a maximum power density of 95 μW cm−2 was obtained at 80 mV.

Graphical abstract: An intravenous implantable glucose/dioxygen biofuel cell with modified flexible carbon fiber electrodes

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Supplementary files

Article information


Submitted
03 Sep 2012
Accepted
03 Nov 2012
First published
07 Nov 2012

Lab Chip, 2013,13, 468-474
Article type
Paper

An intravenous implantable glucose/dioxygen biofuel cell with modified flexible carbon fiber electrodes

F. C. P. F. Sales, R. M. Iost, M. V. A. Martins, M. C. Almeida and F. N. Crespilho, Lab Chip, 2013, 13, 468
DOI: 10.1039/C2LC41007A

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