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Issue 6, 2013
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Engaging isatins in solvent-free, sterically congested Passerini reaction

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Abstract

A facile, atom-economic and environmentally-benign protocol for the synthesis of biologically important oxindole derivatives in high yields has been demonstrated by employing isatins as carbonyl compound surrogates in a Passerini reaction carried out under solvent-free conditions. Moreover, electron-deficient phenols can also be used as the acid component in this reaction. In addition, the synthetic utility of the present methodology was examined by the one-pot synthesis of oxindoles with a free –OH group at the benzylic position.

Graphical abstract: Engaging isatins in solvent-free, sterically congested Passerini reaction

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Supplementary files

Article information


Submitted
08 Mar 2013
Accepted
29 Mar 2013
First published
02 Apr 2013

Green Chem., 2013,15, 1608-1614
Article type
Paper

Engaging isatins in solvent-free, sterically congested Passerini reaction

T. Kaicharla, S. R. Yetra, T. Roy and A. T. Biju, Green Chem., 2013, 15, 1608
DOI: 10.1039/C3GC40454D

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