Jump to main content
Jump to site search

Issue 6, 2013
Previous Article Next Article

Engaging isatins in solvent-free, sterically congested Passerini reaction

Author affiliations

Abstract

A facile, atom-economic and environmentally-benign protocol for the synthesis of biologically important oxindole derivatives in high yields has been demonstrated by employing isatins as carbonyl compound surrogates in a Passerini reaction carried out under solvent-free conditions. Moreover, electron-deficient phenols can also be used as the acid component in this reaction. In addition, the synthetic utility of the present methodology was examined by the one-pot synthesis of oxindoles with a free –OH group at the benzylic position.

Graphical abstract: Engaging isatins in solvent-free, sterically congested Passerini reaction

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Mar 2013, accepted on 29 Mar 2013 and first published on 02 Apr 2013


Article type: Paper
DOI: 10.1039/C3GC40454D
Citation: Green Chem., 2013,15, 1608-1614

  •   Request permissions

    Engaging isatins in solvent-free, sterically congested Passerini reaction

    T. Kaicharla, S. R. Yetra, T. Roy and A. T. Biju, Green Chem., 2013, 15, 1608
    DOI: 10.1039/C3GC40454D

Search articles by author

Spotlight

Advertisements