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Issue 2, 2013
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Direct aerobic oxidation of 2-benzylpyridines in a gas–liquid continuous-flow regime using propylene carbonate as a solvent

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Abstract

The use of high-temperature/pressure gas–liquid continuous flow conditions dramatically enhances the iron-catalyzed aerobic oxidation of 2-benzylpyridines to their corresponding ketones. Pressurized air serves as a readily available oxygen source and propylene carbonate as a green solvent in this radically intensified preparation of synthetically valuable 2-aroylpyridines.

Graphical abstract: Direct aerobic oxidation of 2-benzylpyridines in a gas–liquid continuous-flow regime using propylene carbonate as a solvent

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Article information


Submitted
27 Nov 2012
Accepted
17 Dec 2012
First published
17 Dec 2012

Green Chem., 2013,15, 320-324
Article type
Communication

Direct aerobic oxidation of 2-benzylpyridines in a gas–liquid continuous-flow regime using propylene carbonate as a solvent

B. Pieber and C. O. Kappe, Green Chem., 2013, 15, 320
DOI: 10.1039/C2GC36896J

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