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Issue 2, 2014
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The antioxidant activity of soursop decreases the expression of a member of the NADPH oxidase family

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Abstract

Cellular oxidative stress produced by an increase in free radicals is one of the factors that promote the development of chronic degenerative diseases; therefore, consuming natural antioxidants helps minimize their negative effects. This study evaluated the cytotoxicity of the soursop extract (Annona muricata), its cytoprotective capacity against oxidative stress induced by hydrogen peroxide, the inhibitory potential of reactive oxygen species (ROS), the molecular mechanism of its antioxidant action, and its capacity to repair cellular damage in the fibroblast cell line. The soursop extract proved not to be cytotoxic in fibroblast cultures and showed cytoprotective capacity against hydrogen peroxide-induced stress; in cell culture it reduced the generation of ROS significantly by inhibiting a sub-unit of the NADPH oxidase enzyme (p47phox). The soursop extract can prevent damage caused by cellular oxidants.

Graphical abstract: The antioxidant activity of soursop decreases the expression of a member of the NADPH oxidase family

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Publication details

The article was received on 18 Apr 2013, accepted on 30 Oct 2013 and first published on 01 Nov 2013


Article type: Paper
DOI: 10.1039/C3FO60135H
Citation: Food Funct., 2014,5, 303-309
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    The antioxidant activity of soursop decreases the expression of a member of the NADPH oxidase family

    Y. Zamudio-Cuevas, R. Díaz-Sobac, A. Vázquez-Luna, C. Landa-Solís, M. Cruz-Ramos, M. Santamaría-Olmedo, K. Martínez-Flores, A. J. Fuentes-Gómez and A. López-Reyes, Food Funct., 2014, 5, 303
    DOI: 10.1039/C3FO60135H

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