Issue 27, 2013
From the journal:

Dalton Transactions

Structural and biological implications of the binding of Leu-enkephalin and its metal derivatives to opioid receptors†

Florian Wieberneit,a   Annika Korste,a   H. Bauke Albada,b   Nils Metzler-Nolte*b  and  Raphael Stoll*a  

* Corresponding authors

a Biomolecular NMR, Faculty of Chemistry and Biochemistry, Ruhr-University Bochum, Bochum, Germany
E-mail: raphael.stoll@rub.de
Fax: +49 234 32 05466
Tel: +49 234 32 25466

b Bioinorganic Chemistry I, Faculty of Chemistry and Biochemistry, Ruhr-University Bochum, Bochum, Germany
E-mail: nils.metzler-nolte@rub.de
Fax: +49 234 32 14378
Tel: +49 234 32 24153

Abstract

Binding of Leu-enkephalin and [RhIII(η5-Cp*)(η6-Tyr1)]Leu-enkephalin to the recently published crystal structures of the μ- and δ-opioid receptor is studied. Docking of free Leu-enkephalin reveals two preferred conformations, one of which suggests an alternative binding site for the tyrosine residue. Furthermore, the three-dimensional solution structure of [RhIII(η5-Cp*)(η6-Tyr1)]Leu-enkephalin was solved by using 2D NMR spectroscopic techniques.

Graphical abstract: Structural and biological implications of the binding of Leu-enkephalin and its metal derivatives to opioid receptors

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Article information

DOI
https://doi.org/10.1039/C3DT50635E
Article type
Communication
Submitted
23 Dec 2012
Accepted
08 Mar 2013
First published
22 Mar 2013

Dalton Trans., 2013,42, 9799-9802

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Structural and biological implications of the binding of Leu-enkephalin and its metal derivatives to opioid receptors

F. Wieberneit, A. Korste, H. B. Albada, N. Metzler-Nolte and R. Stoll, Dalton Trans., 2013, 42, 9799 DOI: 10.1039/C3DT50635E

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