Jump to main content
Jump to site search

Issue 15, 2013
Previous Article Next Article

Zinc sensors with lower binding affinities for cellular imaging

Author affiliations

Abstract

Zinc sensors based on 2,3-dipicolylamine (DPA) and quinoline have been synthesized. They fluoresced in the presence of Zn2+ and remained fluorescent when other metal ions were present. Fluorescence enhancement of the sensors was not seen for most other metal ions. In vitro studies with fibroblasts showed fluorescence when sensor and Zn2+ were present. As seen by single crystal X-ray analysis, four nitrogens from the sensor bind to Zn2+. These new sensors have lower binding constants than the pentadentate sensors based on 2,2-DPA.

Graphical abstract: Zinc sensors with lower binding affinities for cellular imaging

Back to tab navigation

Supplementary files

Publication details

The article was received on 17 Dec 2012, accepted on 10 Feb 2013 and first published on 11 Feb 2013


Article type: Paper
DOI: 10.1039/C3DT33024A
Dalton Trans., 2013,42, 5500-5507

  •   Request permissions

    Zinc sensors with lower binding affinities for cellular imaging

    J. H. Kim, I. H. Hwang, S. P. Jang, J. Kang, S. Kim, I. Noh, Y. Kim, C. Kim and R. G. Harrison, Dalton Trans., 2013, 42, 5500
    DOI: 10.1039/C3DT33024A

Search articles by author

Spotlight

Advertisements