Jump to main content
Jump to site search

Issue 9, 2013
Previous Article Next Article

Constructing manmade enzymes for oxygen activation

Author affiliations


Natural oxygenases catalyse the insertion of oxygen into an impressive array of organic substrates with exquisite efficiency, specificity and power unparalleled by current biomimetic catalysts. However, their true potential to provide tailor-made oxygenation catalysts remains largely untapped, perhaps a consequence of the evolutionary complexity imprinted into their three-dimensional structures through millennia of exposure to parallel selective pressures. In this perspective we describe how we may take inspiration from natural enzymes to design manmade oxygenase enzymes free from such complexity. We explore the differing chemistries accessed by natural oxygenases and outline a stepwise methodology whereby functional elements key to oxygenase catalysis are assembled within artificially designed protein scaffolds.

Graphical abstract: Constructing manmade enzymes for oxygen activation

Back to tab navigation

Supplementary files

Article information

31 Aug 2012
03 Oct 2012
First published
04 Oct 2012

Dalton Trans., 2013,42, 3136-3150
Article type

Constructing manmade enzymes for oxygen activation

C. T. Armstrong, D. W. Watkins and J. L. R. Anderson, Dalton Trans., 2013, 42, 3136
DOI: 10.1039/C2DT32010J

Social activity

Search articles by author