Porous silica nanoparticles with mesoscopic void spaces for the domino intermolecular aerobic oxidative synthesis of novel β,β′-diketoenamines

Abstract

Nanosized silica particles of 20–25 nm in diameter were synthesized and characterized by BET, HR TEM, EDX, XRD, ²⁹Si MAS NMR, and FTIR. The silica nanoparticles had nanopores on their surface. It performs efficiently in the multiple component intermolecular domino oxidative synthesis of novel β,β′-diketoenamines without requiring any transition metal catalysts. This is the first report on the so far undiscovered issue of competitive formation of β-enaminones during the 3-MCR (multi-component reaction) involving a 1,3-diketone, aldehyde and amine, and highlights that PSNPs are the stand alone catalyst for selective formation of β-enaminones.